![]() ![]() Įphedrine, a stereoisomer to better-known pseudoephedrine, is a sympathomimetic amine with unique effects due to its indirect mechanism than other sympathomimetic agents like pseudoephedrine and phenylephrine. Lastly, case reports demonstrate using ephedrine to alleviate bronchoconstriction during induction for patients on beta-blocker maintenance therapy. Patients with myasthenia gravis may also benefit from treatment with ephedrine however, evidence for its specific mechanism of action and benefit in this disease has not come from randomized controlled trials, and only observational and non-randomized trials are currently available. However, ephedrine lost favor as a supplement after research established links to ventricular arrhythmias, nausea, and psychiatric issues with use. In the early 2000s, the drug became very popular among over-the-counter supplements because it was found to work synergistically with caffeine to promote weight loss by stimulating metabolism. Other off-label indications include bronchoconstriction, myasthenia gravis, and weight loss(in the past). Oral formulations of ephedrine have been used historically to treat asthma via pulmonary vasoconstriction and reduction in airway edema along with beta-induced bronchodilation, but it is rarely used for this purpose in modern medicine due to unwanted cardiac effects and availability of more selective beta-agonists such as albuterol. Ephedrine is also available in a fixed-dose combination with guaifenesin to temporarily relieve mild asthma symptoms with an expectorant. Due to the constriction of smooth muscle via alpha receptor binding and bronchi dilation due to beta-2 receptor agonism, most sympathomimetics, including ephedrine, work effectively to decrease allergic symptoms. ![]() Most vasopressors used during anesthesia should be viewed as a temporizing measure while determining and addressing the source of hypotension.Īnother notable indication of ephedrine is for allergy relief. Since ephedrine results in both alpha and beta-adrenoreceptor stimulation, it is most beneficial in the setting of hypotension along with bradycardia or a low-normal heart rate, and caution is necessary for patients with hypotension and coexisting tachycardia. However, in the absence of maternal bradycardia, phenylephrine is preferred. According to the American Society of Anesthesiologists Committee Task Force on obstetric anesthesia, ephedrine or phenylephrine can be utilized to treat hypotension during neuraxial anesthesia. It is sometimes given intramuscularly to achieve a longer-lasting effect. Although phenylephrine selection is due to fewer effects on umbilical arterial acidity, ephedrine is a frequent choice due to less alpha-adrenergic action on the uterine vasculature, which preserves uterine blood flow. In obstetrics, sympathectomy during spinal anesthetics results in hypotension in 80% of patients. It is also frequently the agent of choice for hypotension induced by spinal or epidural anesthesia. ![]() Induction of general and ongoing anesthesia during operative cases results in vasodilatation and hypotension, requiring treatment with vasopressors. Should not be used together with any prescription medication, such as antidepressants, stimulants or MAO inhibitors.The FDA-approved primary indication for ephedrine is the treatment of clinically significant hypotension perioperatively. Test your tolerance levels first before deciding to take more capsules throughout the day.Įnergy : Take one or two capsules before training.ĭo not use if pregnant, nursing, breastfeeding, at risk of being treated for heart disease or high blood pressure. When starting out with HYPER BURN, the recommended dosage is one per day, preferably 30 minutes before your workout, 30 minutes before breakfast or first thing in the morning.įat Burning : Take one capsule before breakfast, lunch & training. Preferably take HYPER BURN 45 minutes to 1 hour before meals, but no more than 3 times per day. ![]() Do not take HYPER BURN on an empty stomach. Do not exceed 75-100mg dosages of Ephedrine in 24 hours. HYPER BURN assists in increasing weight loss, heightens athletic performance and boosts energy.Įphedrine dosing schedules may vary in relation to body weight and weight loss goals. When stacked, the combined effects of Ephedrine, Caffeine and Aspirin are far greater than the sum of their effects when used alone. Ephedrine and Caffeine work together synergistically. ![]()
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